Excretion of Metabolites of 7, 12-Dimethylbenz (^|^alpha;) anthracene Injected Intravenously into Rats
نویسندگان
چکیده
منابع مشابه
EFFECT OF IRON OVERLOAD ON 7, 12-DIMETHYLBENZ (A) ANTHRACENE-INDUCED SKIN TUMORIGENESIS
Iron overload is known to occur in the West European and American population due to the consumption of iron-rich diets. On the other hand, genetic disorders leading to iron overload are also known. Iron overload leads to increased peroxidation and disruptive disintegration of lipid-rich membranes, and predisposes humans for an enhanced risk of cancer induction. In experimental animals iron ...
متن کاملThe effect of Ficus carica latex on 7, 12-dimethylbenz (a) anthracene-induced breast cancer in rats
Objective: In traditional medicine, Ficus carica (also known as fig) latex is recognized as a remedy with various therapeutic effects. Recently, in vitro studies have reported the anticancer effect of this latex on cancer cell lines. This study evaluated the effect of this latex on breast cancer growth, hematological parameters, and histopathology in rats. Materials and Methods: Twenty-four fem...
متن کاملComparison of metabolism-mediated binding to DNA of 7-hydroxymethyl-12-methylbenz(a)anthracene and 7, 12-dimethylbenz(a)anthracene.
Comparison of the binding to DNA of 7-hydroxymethyl-12-methylbenza(a)anthracene and 7, 12-dimethylbenz(a)anthracene (DMBA) catalyzed by mouse embryo cells in culture or by rat liver microsomes indicates that the products formed are different for the two hydrocarbons. Thus, the hydroxy compound is not an intermediate in the binding of DMBA to DNA in these systems. Binding of the hydroxy compound...
متن کاملeffect of iron overload on 7, 12-dimethylbenz (a) anthracene-induced skin tumorigenesis
iron overload is known to occur in the west european and american population due to the consumption of iron-rich diets. on the other hand, genetic disorders leading to iron overload are also known. iron overload leads to increased peroxidation and disruptive disintegration of lipid-rich membranes, and predisposes humans for an enhanced risk of cancer induction. in experimental animals iron over...
متن کاملLack of correlation between morphological and biochemical parameters in mammary adenocarcinomas of rats induced with 7, 12-dimethylbenz(a)anthracene.
Mammary tumors induced by 7,12-dimethylbenz(a)anthracene were divided into slowand fast-growing neo plasms on the basis of growth rate. Biochemical and histological evaluation was performed on each group and the data were compared. Of the 21 different parameters ex amined, significant differences were found in 3: isocitrate dehydrogenase and hexokinase activities and triglycéride content. None...
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ژورنال
عنوان ژورنال: The Journal of Kansai Medical University
سال: 1972
ISSN: 0022-8400
DOI: 10.5361/jkmu1956.24.supplement_s130